弁護士谷直樹/医療事件のみを取り扱う法律事務所のブログ

睡眠薬と死亡・発がんリスク,Hypnotics' association with mortality or cancer: a matched cohort study

b0206085_7274944.jpgペンシルバニア州在住で睡眠薬を服用する健康な人1万500人と,睡眠薬を服用しない2万3600人を対象に,平均2年半にわたって観察研究を行っった結果,睡眠薬を服用する人は,死亡リスクが3.6倍から5.3倍高く,発がんリスクが3.5倍高いことが報告されました.

にほんブログ村 士業ブログ 弁護士へ
にほんブログ村

死亡リスクは、1年間の睡眠薬処方が多い人ほど高く,1年間に18服以下しか処方を受けていない人のリスクは3.6倍,1年間に132服を超える処方を受けていた人は5.3倍もリスクが高まっていました.
しかも,これは,観察期間平均2.5年という短い間での差です.

ただ,睡眠薬の副作用で命を縮めているとまでは断言できず,睡眠薬処方を必要とする人のほうがもともと死亡リスクが高い可能性もあります.

Hypnotics' association with mortality or cancer: a matched cohort studyご参照

Discussion
Patients with prescriptions for hypnotics had approximately 4.6 times the hazard of dying over an average observation period of 2.5 years as compared to non-users. These findings were robust with adjustment for multiple potential confounders and consistent using multiple strategies to address confounding by health status. A dose–response effect was seen. Among users in the highest tertiles of annualised dosages, the HRs for death were 5.3, 5.7 and 6.6, respectively, for all hypnotics, zolpidem alone and temazepam alone. This top third of users were prescribed 92.8% of all the prescription doses of hypnotics (supplemental figure 2). Those in the top third were also 35% more likely to develop a new major cancer.

Perhaps the most striking finding was that an increased hazard for death was present even in the lowest tertile of hypnotic use, such that hypnotic drugs were associated with a 3.6-fold increased risk of dying for patients using <18 hypnotic pills per year. Several strategies to discover biases that could account for this hazard, even at low levels of use, revealed none. Nonetheless, some residual confounding is inevitable in our results as a consequence of factors that were inadequately assessed. However, considering the minimal impact of the major confounders for which we did control upon the HRs, we think it unlikely that confounding explains the high mortality that we found associated with hypnotics.・・・・

谷直樹
ブログランキングに参加しています.下記バナーを1日1回クリックお願いします.7日間のクリック数合計が順位に反映します.

にほんブログ村 士業ブログ 弁護士へ
にほんブログ村
by medical-law | 2012-03-02 04:36 | 医療